ImmunoCAP has over 650 different allergens and 90 allergen components for sensitive and precise quantitative detection of allergen-specific IgE antibodies. Serum and plasma (EDTA or heparin) samples from venous or capillary blood can be used for ImmunoCAP testing, and blood can be collected using standard procedures. Specimens can be stored at room temperature for shipping purposes only; otherwise specimens can be stored at 2-8 °C for up to one week, or -20 °C for longer. Specimens should not be repeatedly frozen and thawed.
Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.
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Allergy & autoimmunity product catalogue 2016
IgE antibodies appear in human serum and plasma as a result of sensitisation to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitisation to an allergen. In general, low IgE antibody levels indicate a low probability of clinical disease, whereas high antibody levels to an allergen show good correlation with clinical disease.
From an allergen source, single allergen components can be produced. Sensitisation to these components is then measured individually in separate tests, helping to pinpoint, on an exact molecular level, which component the patient is sensitized to. This information provides the basis for a refined diagnosis of the allergy. Different components are associated with different degrees of risk:
CCDs: Cross-reactive carbohydrate determines
PR-10: Pathogenesis related family number 10
nsLTP: Non-specific lipid transfer proteins
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